Alice in Chains,Soundgarden,Pearl Jam,Temple of the Dog,Nirvana are a few from around my area

Closest city to me is NYC. Talking Heads and Ramones come to mind.

The Doors
The Seeds
The Music Machine
Love
Eddie Cochran
The Dickies

Zuruckspulen, Plike, Blunt Force Trauma, Synthentral, Splendid Obsolescence, Meat Puppets, and of course Jimmy Vaugn and Eric Johnson.

personally : Harmonium and beau dommage, but the most well known outside of Quebec are probably arcade fire, simple plan, men without hats and april wine.

None originated in my home city. I grew up in a tiny little southern town about an hour from Nashville. Lots of stars came from Nashville though!

Santana
Green Day
Journey
Faith No More
Jefferson Airplane
The Grateful Dead
Sly And the Family Stone

Boo!