Someone please tell me what to do in this situation.

I have a best friend that I don't see very often, she's found some new best friend's,which didn't bother me at first but recently her new best friend has been trying to poke fun at me on my comments and I've also noticed that when this started,my best friend has been kinda off too. She can post something and 10 people will comment including myself and she will respond to everyone but mine. I get a thumbs up . I've been trying to check on her because she's been having family problems,she will respond in a very short manor but will ignore any specific questions about how her family is doing.

Now I know that I'm not normal,I have bipolarII extremely high anxiety and I'm borderline agoriphobic ( have been for the past three years) we don't get to hang out anymore because her new best friend (I'm glad she has someone,a new best friend because I never want her to be money but at the same time my heart is breaking.
I don't want to quite trying but it seams the more I try,the more I feel I've lost me best friend.

I feel so alone right now.