Relocating

I am planning to relocate in the next 3 to 6 months. I work with the same company for three years and plan on transferring so I'll have work. I'm thinking about Nevada but haven't picked a city yet. In full disclosure I am a trans woman so I am also asking this question in regards to safety and making social circles in my new city. What are some of the pros and cons of living in Nevada? Safety? Good places to go to make friends only? Not looking for dates or hook ups. I'm also an artist, I play guitar and paint. So art scenes and circles? I know this is a lot of questions and hoping I can get some good pointers or at least pointing in the right direction.