Do you believe in the subjectivity of reality?

Our brains cannot see, feel, hear, taste, or smell. These are all perceptions your brain picks up from sensations and waves. This reality, quite possibly, could be entirely made up. It is entirely made up.
When on acid, your perception of reality is so easily skewed because of how easily your brain can pick up false waves, or even enhance things that are really happening, from things you believe may be there. This is also so with those who are schizophrenic.

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SteelHands · 61-69, M

The question answers itself. The blending of perceptions that drugs like lsd cause on the gamglionic sensory regions of the brain confirm that reality is real by providing a range of ambiguous subjective experiences by the physical matter of the drug in question. Supremely so, as finding that the brain rebalances its self near as functionality can allow after a given time of exposure.

This would be analogous to throwing a bucket of sand into a Swiss clock and not having it bring the clock into a state of questionable fitness to rely on telling the time of day.

Even with increases in tolerance through the built in brain biochemistry compensator self repairing structures.

The brain has both amazing plasticity and resillience, just like the natural world that it senses as it's environment, even though that environment has a certain mallabillity or plasticity of its own.