Can the same language mean different things in different cultures?

Is it difficult for someone English to be friends with an American? Can there be misunderstandings due to words having very different meanings on each side of the pond? It seems like it is relatively easy to insult an American with absolutely no intent whatsoever? Anyone experienced this? What did you do to remedy the situation?

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HannibalAteMeOut · 22-25, F

I don't think it's that easy to insult someone because context is a great clue, plus they would know you're from a different culture so they would likely ask what you meant before getting offended. That reminded me how in my own language I often use a word that signifies something bad, but I use it for something cute/sweet and people get confused until I explain it to them lol but it's a regional thing I guess that I've picked up from my place of origin. The key is that people should ask before assuming anything bad if they don't understand something.