Getting old can really suck. Really.

@BlueVeins thank you blue. But i am aged enough as reversal seems...unnecessary. i will continue to age as ungracefully as possible.

@BlueVeins @Carla Using rapamycin for age-suppression is highly theoretical and experimental at this point with no way to test it for practical purposes for today's population as it would literally require someone's lifetime to prove it. In the meantime, there are as many alarms about it's efficacy as there are suggestions it could work by accomplishing what is believed to results from severe calorie restriction.

In this case, you would be better experimenting with an injection of bleach or UV light or taking a dose of hydroxychloroquine.

@MarkPaul No, you don't. First of all, you can just give a drug to people while they're near the end of their lifespan to see if they die later, doesn't take a whole lifetime. Second of all, if the goal is to slow aging, you can just give it to people for a few years and check biomarkers of aging before and after to see what happened. The results of a study attempting to do the latter are going to be released very soon.

@BlueVeins I agree it offers an exciting premise and there are some positive indicators it could actually hold promise. But, there are also indicators it might not be able to live up to the hype. At least the studies I have read mention that those involved with giving forms of the drug to elderly people have not been successful.

Keep it mind, it isn't presented as a way to reverse aging, it's intended to slow down age related declines. So, administering it to someone in an end-of-life scenario isn't really definitive, one way or another as a successful treatment. I have read something about an aging study being done on dogs as a proxy for humans. No doubt, this is an interesting area that could lead to positive results in the future. I suspect it won't be soon though.

@MarkPaul What human studies on rapamycin's anti-aging properties have you found? I've looked all over for that shit and haven't found anything except the PEARL trial currently in progress.

@BlueVeins This is one site I used for a topic I was researching when I was still in school and trying to keep up with: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00062-3/fulltext

I first heard about mTOR inhibitors like rapamycin in an interview the actor Michael J. Fox gave about his Parkinson's. I don't recall what role, if any, he or his organization has in it, but he mentioned it as offering a potential exciting outcome for that could slow the decline of age-related diseases such as Parkinsons.

This is hardly definitive and these studies are in the very early stages, I know, but it does seem like there is promise, just not anytime soon.

@BlueVeins One issue with drugs and old people is that they may not have the capacity to know if they are better with the drugs or not, and with physical changes that go with aging, side effects are difficult to sort out.

In the few cases I studied the testing phase of FDA drug approval, I've noticed the seemingly tiny numbers of old people included in the testing population, and what seems like a lack of accountability for age when determining appropriate dosage.