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Publication showing Ivermectin of no use treating COVID

Another science-based report that the use of ivermectin is not indicated in treating mild to moderate covid infections. When will the non-scientists start believing in science?

IMPORTANCE The effectiveness of ivermectin to shorten symptom duration or prevent
hospitalization among outpatients in the US with mild to moderate symptomatic
COVID-19 is unknown.
OBJECTIVE To evaluate the efficacy of ivermectin, 400 μg/kg, daily for 3 days compared with
placebo for the treatment of early mild to moderate COVID-19.
DESIGN, SETTING, AND PARTICIPANTS ACTIV-6, an ongoing, decentralized, double-blind,
randomized, placebo-controlled platform trial, was designed to evaluate repurposed
therapies in outpatients with mild to moderate COVID-19. A total of 1591 participants aged 30
years and older with confirmed COVID-19, experiencing 2 or more symptoms of acute
infection for 7 days or less, were enrolled from June 23, 2021, through February 4, 2022,
with follow-up data through May 31, 2022, at 93 sites in the US.
INTERVENTIONS Participants were randomized to receive ivermectin, 400 μg/kg (n = 817),
daily for 3 days or placebo (n = 774).
MAIN OUTCOMES AND MEASURES Time to sustained recovery, defined as at least 3
consecutive days without symptoms. There were 7 secondary outcomes, including
a composite of hospitalization or death by day 28.
RESULTS Among 1800 participants who were randomized (mean [SD] age, 48 [12] years; 932
women [58.6%]; 753 [47.3%] reported receiving at least 2 doses of a SARS-CoV-2 vaccine),
1591 completed the trial. The hazard ratio (HR) for improvement in time to recovery was 1.07
(95%credible interval [CrI], 0.96-1.17; posterior P value [HR >1] = .91). The median time to
recovery was 12 days (IQR, 11-13) in the ivermectin group and 13 days (IQR, 12-14) in the
placebo group. There were 10 hospitalizations or deaths in the ivermectin group and 9 in the
placebo group (1.2%vs 1.2%; HR, 1.1 [95%CrI, 0.4-2.6]). The most common serious adverse
events were COVID-19 pneumonia (ivermectin [n = 5]; placebo [n = 7]) and venous
thromboembolism (ivermectin [n = 1]; placebo [n = 5]).
CONCLUSIONS AND RELEVANCE Among outpatients with mild to moderate COVID-19,
treatment with ivermectin, compared with placebo, did not significantly improve time to
recovery. These findings do not support the use of ivermectin in patients with mild
to moderate COVID-19.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT04885530

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TexChik · F

Tell that to the tens of thousands in India that were saved by Ivermectin in combination with quercetin, Vit D, Zinc, and Vit A. People stopped dying and became symptom and virus free in 5-7 days. My neighbor went over there and volunteered . It worked. Big pharma wants everyone injected and dying ,not getting well

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Crazymatt · 31-35, M

@TexChik joe rogan swears by it too!

samueltyler2 · 80-89, M

@TexChik did you even read the article, do you have any idea how medications are studied fir effectiveness. You are demonstrating your lack of willingness to accept the results of a rigorous, well designed, double-blind, control study, that is the most valuable way to study effectiveness of medications. If you need to learn and understand that, i suggest you study research design. Of course some people get better in 5-7 days, as did the study subjects given placebo, but those getting ivermectin did not fair any better. This the treatment with ivermectin was not superior to placebo!

TexChik · F

@samueltyler2 I read a big pharma article. I guess you should go tell all those Indians to die, but instead they didnt listen to you or big pharma and took what was available. Ivermectin is an old world drug that has been used for over 100 years successfully .

samueltyler2 · 80-89, M

@TexChik you are very wrong about everything even about ivermectin being an "old world" drug, i am not even sure what that is. It is used in some parasitic diseases, but has never been shown efficacious in treating covid. The doses need to achieve the blood levels in on vito studies in viral and infections would cause serious toxicities in patients. Get knowledge based information or shut up.

Diotrephes · 70-79, M

@TexChik Take, or don't take, whatever you want to. If you die as a result I don't care.

TexChik · F

@Diotrephes I did take, got rid of my lingering symptoms from when I had covid. I am perfectly fine, my family never got it. You should get a few more boosters, I hear they are really good for your health, and if I'm wrong, I certainly wont care.

Diotrephes · 70-79, M

@TexChik Well, they have worked for me so far. I haven't gotten sick from the virus, the flu, or the vaccines. Of course I will eventually get sick from something and die as a result but that's life on this planet. In the meantime I hope to be smart enough to give me the best chance to continue living without getting sick from preventable causes.

TexChik · F

@Diotrephes I hope you do too. If your age on your profile there is accurate you are not the one in danger. Its the 20-40 crowd dyin off world wide. Canada is running out of doctors. They are dying

samueltyler2 · 80-89, M

@TexChik okay, i try hard to avoid direct confrontations, but, again where do you get your crazy data? The age at greatest risk of serious illness and death are those over 60. Yes, that still leaves a huge number of younger adults, and even children, who die. Please look at the data before you post incorrect statistics. We are seeing a drip on physicians, because of burn out, causing them to leave practice, not because so many are dying. But, if it were true that they are dying, what are tying from. Some of your friends on SW seem to believe COVID doesn't even exist, that it is all a hoax, a conspiracy.

TexChik · F

@samueltyler2 From a doctor who went to India and saved countless lives by dosing with Ivermectin and the other drugs I mentioned, Youtube deleted any video that showed that...why?

samueltyler2 · 80-89, M

@TexChik i know you won't believe me, but because social media had determined that they may be liable for publishing false and dangerous information. The information regarding danger versus ineffectiveness of ivermectin is so clear as to make publishing information to the contrary could result in serious financial vulnerability.

TexChik · F

@samueltyler2 prior to big pharma making vaccine, there was no such warning about Ivermectin

samueltyler2 · 80-89, M

@TexChik what? Ivermectin was incredibly important in treating a parasitic infection. There was no warning because used in appropriate doses it prevented blindness without significant side effects. Early in the covid outbreak, scientists started screening medications fir possible use. They did find ivermectin could interfer with viral replication. Unfortunately, to achieve that effect, require very high concentrations. To achieve tissue levels that high, would require enormous doses, which would produce serious side effects. Then, despite this, there were those who decided to use it. That led to earnings. It had nothing to do with vaccine. Thank goodness the research on mRNA vaccines which began in the 1990s revealed that the mRNA technology could be used to produce an effective vaccine in a shorter period of time than other techniques. The vaccine Ed has saved tens of millions of lives.

TexChik · F

@samueltyler2 The cat is out of the bag on the vax, big pharma has already admitted natural immunity is more effective and also said it was never intended to prevent the spread . Far too many lies about the death totals, far too many lies about the side effects, far too many libs have been given a pass on having to take it at all. Never trust a liberal.

samueltyler2 · 80-89, M

@TexChik OMG, so your true colors have now come out. Your comments are pure political nonsense. No one cares of your impression about natural versus vaccine-related immunity. You do realize that millions of lives have been lost to the natural infection. Do some mathematics to see how many more would due without the vaccine. Are you really suggesting that we abandon vaccination and simply allow the virus to run it's course? Let us this do the same for all immunizations, how many innocent people will then perish.

TexChik · F

@samueltyler2 How many are dying now because of the vaccine ? To fight the manmade virus the libs and china made. Now only those who are vaxxed get sick and die from the virus. Coincidence? I think not. The covid vaxx is not an immunization and we are not talking about time tested safe and effective vaccines. Not this back room brew even Phizer's own CEO wont take

Diotrephes · 70-79, M

@TexChik

I hope you do too. If your age on your profile there is accurate you are not the one in danger. Its the 20-40 crowd dyin off world wide. Canada is running out of doctors. They are dying

This topic is like all of the others. Some people are willing to see danger and take steps to protect themselves while others will ignore it and end up suffering the consequences, even death.

We will all avoid the many thousands of things that can kill us except for one thing. I personally know people who refuse to get recommended vaccinations. They are still alive. But if they do come down with a virus and get seriously sick or even die as a result I won't shed a tear for them. It's their choice and I respect it. In the meantime I will take reasonable steps to give myself the best chance of avoiding the most common dangers.

So, do what you think is best for yourself. I respect your decision. After all, we are all going to die anyway so live your life as you see fit.

TexChik · F

@Diotrephes They wont, but people like you who are vaxxed and boostered are. That's the cold hard facts of it.

Diotrephes · 70-79, M

@TexChik Take care and stay safe.

samueltyler2 · 80-89, M

@TexChik you know, it is useless to argue with someone who had as closed a mind as you have. Make your own decisions for yourself, but please stop posting dangerous false information. There are at least 2 post immunization surveillance systems to pick up any signal of dangerous side effects of the vaccine. Look at VAERS and vSafe, check yourself. Whereas some who were immunized still do become infected, and some may even die, but, the vast majority of those who die, were never immunized!!!

If you don't believe me, then do your own study of the literature. Listen to the people on the front lines of therapy, not the internet news blogs.

I give up with you and am going to bed.

TexChik · F

@samueltyler2 either you are sadly ignorant of the devastating side effects or complicit. Stop trying to BS me .

samueltyler2 · 80-89, M

@TexChik good night, you are the one either totally ignorant, or so badly brain washed that you are unable to see the light in front of you.

Good luck, i pray that you are okay and don't end up as a statistic.

Ontheroad · M

@TexChik I am living proof you are wrong... as usual. I was in the target group for being the most likely to contract Covid-19. I was over 60, and had just been diagnosed with cancer, and was undergoing chemo and radiation treatments when the virus hit. You do not get more susceptible than that. For over two years I fought the cancer, had my immune system destroyed by life saving chemo and radiation, underwent two grueling surgeries, and underwent yet more chemo treatments... all the while Covid was raging and because of my situation was given early on doses of the vaccine, plus follow up boosters (a total of 5 to date) and never once had the first signs of Covid. I discussed Ivermectin with my doctor, both of my oncology doctors and three separate infectious disease doctors... they all to a person rejected its use. They told me, in a word, anyone who relied on it was a fool. Glad I listened to the experts, which you ARE NOT.

TexChik · F

@Ontheroad You are living proof youre a lib. Glad we have different doctors

Ontheroad · M

@TexChik You are a sad person... really sad. You want to turn everything into political rhetoric. Too bad you don't have a life.

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