How can you recover professionally after being fired for something you said in the heat of the moment?

How do I stop being the "responsible" one? People close to me (including family) put all the burden and sins of other people into me in hopes of me fixing them all. I used to help them out but how do I stop?
If I tell my sister (who thinks she's a guy) that I no longer support gender ideology and won't call her a man any longer, is it possible to do it gently without provoking her into a homicidal frenzy?