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Question about Covid Vaccine in regards to pain meds

My dad had a shot of Astra Zeneca a little over a week ago. He hasn't experienced any side effects but he finds now his pain medication has no effect. It may not be related to the vaccine but normally he's very sensitive to it a pill would be more than enough he tried one it had no effect and the next day he took 2 pills which would probably have him on another planet and there was again zero effect nothing positive or negative it was like he took nothing. Has anyone heard of this being a side effect to the vaccine?
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I hadn’t heard about this as a side effect, but it’s definitely possible. It’s new, so there could be interaction with other drugs in general. I read that you spoke with his doctor about it ?
@bijouxbroussard I mean spoke to his doctor meaning he called him and got the typical, should be fine, response.