how should you respond to the times you get 'negative' replies and people not validating you

and people not responding to you, online i mean? this really gets to me at times...my loved ones tell me, this happens to everyone online at one time or another, bottom line; not just me ....but when it happens to me, i really take it to heart and i instantly feel angry, also ' at a loss ' too sometimes, at why i'm getting those replies in the first place??.....usually when i get really angry i can't think of anything to comeback with or can't think of clever responses? my instinct is to get aggressive....but i know that is not the way.

so how should you respond to those times when online??