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Question for other long term heavy smokers...

Like 10+ year smokers... when did you start noticing any health effects and how bad were they?
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My grandfather once told me he started smoking when he was about 12. He smoked cigarettes (Camels) and later, a pipe. He also drank bourbon. He was diagnosed with cancer at the age of 95 and passed away, in his sleep, about a month after the diagnosis. Two weeks after telling me, when he said, "Oh, well…that’s the way the cookie crumbles, yes ?" R.I.P.