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From your perspective, how can a person thoroughly screw-up his/her life?

What is the most effective way you can come up for screwing everything in life? Explain. Thank you :)
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UnfulfilledYetWise
Give into all impulses without regard for the consequences. Such a person will sooner, rather than later, end up dead or in prison for a very long time. When we use our freedom to choose to participate in less than ideal behavior, we get to pick what we do, but we do NOT get to pick the consequence of our actions. The two, your choice and its accompanying consequence, are inextricably linked. If you select a course of action, you also select its consequences, although you may not recognize it until later.