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When actors play drug addicts in movies, are they affected by the drugs they have to take?

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Jayzed · 18-21, M
When actors do drugs during a scene?
Most of the drugs are fake (Such as coke and all that) and uses special effects to make it look like the user took it. But for needles, I think it's a fake needle as well (Needle is dull and retracts into the bottle and nothing really injects, but taken out it is all okay and empty) Or it is just special effects again.

Not sure this is true but those were my thoughts.