I Am Trying to Educate People About Alzheimer's
Supplement Recommendations For Those At Risk Of Alzheimer's Or In Early Stage Dementia... The Life Extension foundation makes these recommendations on supplementation for those at risk of Alzheimer's or in early stages of dementia.
http://www.lef.org/newsletter/2009/0811_Mediterranean-Diet-Alzheimers-Disease-Cognitive-Decline.htm?utm_source=eNewsletter&utm_medium=email&utm_term=Archive&utm_content=Update&utm_campaign=2012Wk4-2
The most exciting research today in Alzheimer’s disease focuses on the role of inflammation and oxidative stress, as well as the role of receptors in reducing glutamate excitotoxicity. Alzheimer’s disease, like so many other diseases, is being redefined as an inflammatory condition in which excess pro-inflammatory chemicals in the body cause damage to normal healthy cells. Although most doctors remain unaware of this developing hypothesis, the Life Extension Foundation has assembled the latest research to provide a comprehensive approach to preventing Alzheimer’s disease.
There are many choices of both drugs and nutritional supplements available for patients with Alzheimer's disease. In light of new evidence that oxidative stress and inflammation are central to Alzheimer’s disease, people at risk of Alzheimer’s (or those who have early dementia) are advised to take supplements that reduce inflammation and oxidative damage. These include:
* Curcumin—900 to 1800 milligrams (mg) daily
* EPA/DHA—1400 mg daily of EPA and 1000 mg daily of DHA
* Vitamin E—400 international units (IU) daily (with 200 mg of gamma-tocopherol)
* Vitamin C—1 to 3 grams daily
* Ginkgo biloba—120 mg daily
* Acetyl-L-carnitine arginate—750 to 2000 mg daily
* CoQ10—100 to 600 mg daily
* N-acetylcysteine—600 mg daily
* Aged garlic—1200 mg daily
* Vinpocetine—15 to 20 mg daily
* Green tea extract (93 percent polyphenols)—725 mg daily
* B vitamins—A full complement of B vitamins (including folate, vitamin B6, and vitamin B12) to lower homocysteine. Specific suggested doses include 1000 micrograms (mcg) of vitamin B12, 250 mg of vitamin B6, and 800 mcg of folic acid.
* Niacin—Up to 800 mg daily. Start slowly and take with food to avoid flushing.
* Melatonin—1 to 3 mg each night
* DHEA—15 to 75 mg daily. Have blood tested in 3 to 6 weeks to determine optimal dose.
* Huperzine—50 mcg up to four times per week
* Blueberry extract—500 to 2000 mg daily. If you eat blueberries, you don’t need to take this much blueberry extract.
* Grape seed extract—100 mg daily
Conceptualclarity : I would add that for most of these supplements, the levels should not be looked upon as absolute ceilings, particularly for persons with Alzheimer's. Much higher levels of pharmaceutical grade fish oil have proven very beneficial against serious brain health conditions. A Columbia University study found 2,000 IU of Vitamin E to be more effective for Alzheimer's than the drug selegiline. Following LEF's guidelines, that level of d-alpha tocopherol Vitamin E should be coupled with 1,000 mg of gamma tocopherol.
It is believed that controlling homocysteine is important in preventing Alzheimer's. This is reflected in the recommendations for B vitamins and aged garlic. Lowering blood glucose levels by adopting a lower glycemic load diet, substituting vegetables for sweets and starchy carbohydrates, is also considered very important.
http://www.lef.org/newsletter/2009/0811_Mediterranean-Diet-Alzheimers-Disease-Cognitive-Decline.htm?utm_source=eNewsletter&utm_medium=email&utm_term=Archive&utm_content=Update&utm_campaign=2012Wk4-2
The most exciting research today in Alzheimer’s disease focuses on the role of inflammation and oxidative stress, as well as the role of receptors in reducing glutamate excitotoxicity. Alzheimer’s disease, like so many other diseases, is being redefined as an inflammatory condition in which excess pro-inflammatory chemicals in the body cause damage to normal healthy cells. Although most doctors remain unaware of this developing hypothesis, the Life Extension Foundation has assembled the latest research to provide a comprehensive approach to preventing Alzheimer’s disease.
There are many choices of both drugs and nutritional supplements available for patients with Alzheimer's disease. In light of new evidence that oxidative stress and inflammation are central to Alzheimer’s disease, people at risk of Alzheimer’s (or those who have early dementia) are advised to take supplements that reduce inflammation and oxidative damage. These include:
* Curcumin—900 to 1800 milligrams (mg) daily
* EPA/DHA—1400 mg daily of EPA and 1000 mg daily of DHA
* Vitamin E—400 international units (IU) daily (with 200 mg of gamma-tocopherol)
* Vitamin C—1 to 3 grams daily
* Ginkgo biloba—120 mg daily
* Acetyl-L-carnitine arginate—750 to 2000 mg daily
* CoQ10—100 to 600 mg daily
* N-acetylcysteine—600 mg daily
* Aged garlic—1200 mg daily
* Vinpocetine—15 to 20 mg daily
* Green tea extract (93 percent polyphenols)—725 mg daily
* B vitamins—A full complement of B vitamins (including folate, vitamin B6, and vitamin B12) to lower homocysteine. Specific suggested doses include 1000 micrograms (mcg) of vitamin B12, 250 mg of vitamin B6, and 800 mcg of folic acid.
* Niacin—Up to 800 mg daily. Start slowly and take with food to avoid flushing.
* Melatonin—1 to 3 mg each night
* DHEA—15 to 75 mg daily. Have blood tested in 3 to 6 weeks to determine optimal dose.
* Huperzine—50 mcg up to four times per week
* Blueberry extract—500 to 2000 mg daily. If you eat blueberries, you don’t need to take this much blueberry extract.
* Grape seed extract—100 mg daily
Conceptualclarity : I would add that for most of these supplements, the levels should not be looked upon as absolute ceilings, particularly for persons with Alzheimer's. Much higher levels of pharmaceutical grade fish oil have proven very beneficial against serious brain health conditions. A Columbia University study found 2,000 IU of Vitamin E to be more effective for Alzheimer's than the drug selegiline. Following LEF's guidelines, that level of d-alpha tocopherol Vitamin E should be coupled with 1,000 mg of gamma tocopherol.
It is believed that controlling homocysteine is important in preventing Alzheimer's. This is reflected in the recommendations for B vitamins and aged garlic. Lowering blood glucose levels by adopting a lower glycemic load diet, substituting vegetables for sweets and starchy carbohydrates, is also considered very important.
