Is it okay to tease someone of their weakness? Or something that makes them insecure about themselves?

For example, someone has unattractive body figure or face or anything that make them looked... let just say unattractive or below average whatever as long you understand what I am saying.

Anyway, I find it is irritating when someone use my flaw as joke 24/7. The joke gets old and I am no longer amused by it. Like, is that only what you got?