Do you think you can be depressed and in a relationship at the same time?

Im with a decent, nice person. Feels like i just cant do it. I cant express myself to anyone because at this point i just feel fed up with the kind of negstive person that i am. I'm tired and I cant believe Im going to lose a person I care about over feeling constantly like shit.
Nothing works, everything is a waste of time, meds get you addicted and once you re off them you get terrible withdrawal symptoms. Damn there s no point to anything.