The Y chromosome is disappearing, and this fact is already causing problems for men

That's actually really sad but you can offset the loss of a chromosome to make yourself more healthier as a male (below.) I didn't know the Y chromosome was linked to the immune system so they are finding that as men age, they are losing their Y chromosome as it sometimes mis-segregates. This is causing problems as those with a loss of the chromosome died 5.5 years earlier, suffered more heart disease and a 7 fold rise in Alzheimer's. They also studied mice bred without the chromosome and transplanted them. Found that the recipients have developed fibrosis, failing hearts and early death, showing the direct loss is the culprit, not merely a bystander.

Cigarette smoke, air pollution, and certain industrial chemicals add extra DNA damage and accelerate the Y chromosome loss. Kicking tobacco, breathing cleaner air, and limiting exposure to mutagens therefore rank as simple defenses – all it takes is willpower.

General habits that slow genomic wear – regular exercise, Mediterranean-style meals, and solid sleep – may also keep the Y chromosome in more cells for longer.

Antifibrotic drugs cleared for lung disease are being tested to blunt heart damage from the loss. Oncologists already use chromosome status in bladder tumors to steer checkpoint therapy.

As single-cell sequencing gets cheaper, your physical exam might soon include a “Y-loss score” beside cholesterol.

https://www.earth.com/news/y-chromosome-is-disappearing-may-already-be-causing-problems-for-men/