The Y chromosome is disappearing, and this fact is already causing problems for men

That's actually really sad but you can offset the loss of a chromosome to make yourself more healthier as a male (below.) I didn't know the Y chromosome was linked to the immune system so they are finding that as men age, they are losing their Y chromosome as it sometimes mis-segregates. This is causing problems as those with a loss of the chromosome died 5.5 years earlier, suffered more heart disease and a 7 fold rise in Alzheimer's. They also studied mice bred without the chromosome and transplanted them. Found that the recipients have developed fibrosis, failing hearts and early death, showing the direct loss is the culprit, not merely a bystander.

Cigarette smoke, air pollution, and certain industrial chemicals add extra DNA damage and accelerate the Y chromosome loss. Kicking tobacco, breathing cleaner air, and limiting exposure to mutagens therefore rank as simple defenses – all it takes is willpower.

General habits that slow genomic wear – regular exercise, Mediterranean-style meals, and solid sleep – may also keep the Y chromosome in more cells for longer.

Antifibrotic drugs cleared for lung disease are being tested to blunt heart damage from the loss. Oncologists already use chromosome status in bladder tumors to steer checkpoint therapy.

As single-cell sequencing gets cheaper, your physical exam might soon include a “Y-loss score” beside cholesterol.

https://www.earth.com/news/y-chromosome-is-disappearing-may-already-be-causing-problems-for-men/

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exchrist · 31-35

Might the practice of circumcision, at time of birth, be leading to an evolutionary dissapearance of the Y chromosome?
If life adapts to avoid suffering, and the first thing males experience after birth is circumscision. One might expect that, to avoid suffering, the Y chromosome will steadily fade away; to avoid the pain of circumcision.
So if we end circumscision at birth perhaps the Y chromosome will a) become more resilient? b)Regain its original size And c) result in a greater fitness of the genes contained within that minor chromosome within the pair(Xy).
How would we know the genes that should be being expressed if we only lop them off before they can even be expressed prior to ever reaching maturity?
By tradition it should remain intact at least until the second week of life (in christianity- a christening) until reaching puberty (roughly age 13 in judaism- a bar mitzfah) and never removed in Islam?(usually around age 7).

Also are the genes that are requirements of life more present on the X chromosome? Organ development\formation and function being my main hypothesis.
Save men (the Y chromosome) stop circumcision!
In the interest of satisfying women, stop cutting boys!

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exchrist · 31-35

@SatanBurger thats interesting the irrational chromosome. Could be a good series. But yes it seems testosterone makes men more prone to rash decisions. Reckless. . . Other organisms have lost the male gene? Interesting! might you have a source i could read up on?

SatanBurger · 36-40, F

@exchrist I wasn't I was responding to your theory or just adding into it

exchrist · 31-35

@SatanBurger ah ok i thought maybe we could hypothesize humans moving toward losing toxic masculinity. A uptopian idea?

basilfawlty89 · 36-40, M

Theoretical stuff here, but I wonder if as senolytics advance, they may help slow or even reverse this.

exchrist · 31-35

In Hinduism (the most followed religion in the world; by population) the oldest there are 9 recognized forms of gender and according to wikipedia
"Hinduism discourages non-medical circumcision, as according to them, the body is made by the almighty God, and nobody has right to alter it without the concern of the person who is going for it."
Reported rate of circumcision in India about 16%.

badminton · 61-69, MVIP

But...but... I have a Y chromosome,

Tastyfrzz · 61-69, M

https://en.m.wikipedia.org/wiki/Behavioral_sink

SatanBurger · 36-40, F

@Tastyfrzz Interesting

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