What would YOU do?

My sister has had an undiagnosed condition for three years now... twitching in her legs daily, muscle pain like you just ran 1000 miles, and leg fatigue. She has seen neurologists, physical therapy, rhematoid doctors and her PCP. Multiple MRIs and blood work. All negative. She's had some genetic testing...that was negative. She has wanted to end her life because the symptoms are there EVERY day, all day. She tried to do a study, but was rejected as they could only accept so many participants. She's at a dead end, what would you do? She does have another appointment with a sixth neurologist, but that may lead to no answer as well. Any ideas?

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SW-User

Tell her to STOP drinking coffee

My Sis had the same.

Stopped when she quit coffee

Coralmist · 41-45, F

@SW-User wow She had the symptoms of horrible leg pain, stiffness, twitches 24/7? I drink coffee and dont have my sisters condition...🤔

SW-User

@Coralmist Because caffeine is a stimulant, it can interfere with sleep if it’s consumed too close to bedtime. It’s long been on the list of restless legs triggers, but Dr. Salas says recent research shows it may not be that big of a problem. In fact, she says, it may be beneficial in some people. Try cutting out coffee, tea, colas, sports drinks, and even chocolate to see if your symptoms improve or worsen.

Clinical study of 362 patients with restless legs syndrome and associated anxious-depressed and other clinical states seems to indicate that caffeine is the major etiological factor in the causation of the restless legs syndrome. Anxiety, while modifying the subjective experience of the dysphoric sensation of restless legs, is not a causative factor. Caffeine is responsible for the increased nervous system arousal as well as for the direct peripheral contractile effect on the striated muscle. This arousal is often reflected psychologically in anxiety and sometimes depressive manifestations, insomnia, heightened proprioceptive awareness and physiologically in the toxic sensory experience of restless legs associated with increased neuromuscular reactivity which may include myoclonus and myokomia.