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You can't ever be 100% sure on an individual level. Severe side effects are incredibly rare, but they do happen. The only way to know you're not a one in a hundred million unlucky person is by taking it and experiencing no major negative effects.
Other than that, the basic technology is over 2 decades old so we can be pretty sure about how rare long term damage is for the population or average person.
Other than that, the basic technology is over 2 decades old so we can be pretty sure about how rare long term damage is for the population or average person.