So what's bothering you at the moment?

Since I'm at the Dr's office lol.. this one is for my sister...she wonders how to manage through a day...she feels like ending her life most days :( She feels hopeless, they cannot find a diagnosis or med that helps her neverending pain in her legs (and twitching in legs). It has led to depression, she's had to even visit a psychiatric unit for how low she felt. It is so sad to see her feel so hopeless and like she isn't even in her body anymore; like a derealization.