How to communicate with someone that believes you are the problem

It’s been really frustrating lately. Often when I say something to my wife she jumps to conclusions about what I’m trying to say and my motivations ( which she claims are mostly negative). Doesn’t matter if I try to clarify or tell that isn’t what I’m talking about nor was it my intention. At that point it no longer matters to her what I was trying to say and she get even more angry that I’m still talking about it.