MTHFR and the Methylation Cycle

This is what I am finally learning about. I have known for over 10 years that I had 2 MTHFR variants (C667T and A1298C variants). Also called Compound Heterozygous. I knew that this made the methylation cycle(whatever that was) not work well. I thought I could just take the supplements and not worry about it, but after a while, I kinda started thinking I didn't need to take the supplements or to worry about the MTHFR. So, I started taking them only when I felt bad. 😔

It is a little rare to have both variants.

"Understanding the Variants
C677T Variant: This variant is more prevalent, affecting around 30-40% of certain populations, especially among those of Hispanic descent.

A1298C Variant: This variant is less common, found in about 7-12% of individuals in North America and Europe.

Having both the C667T and A1298C variants of the MTHFR gene is relatively uncommon. Estimates suggest that this combination occurs in approximately 10-20% of the population. Having both the C667T and A1298C variants of the MTHFR gene is relatively more common among European populations."
GPT-4o mini


I recently started having very mild memory problems, and I felt it pressed on me to start taking all my supplements again and to learn more about the methylation cycle. It is a little harder to figure this all out now that I am having some brain issues. It would have been easier to figure out last year, but I will get this figured out. I am now taking a gazillion supplements, and I do think it is helping. 👍

From what I am now learning, the Methylation Cycle is very very important, and I should have taken it seriously years ago. Live and learn,I guess. 🤦‍♀

https://www.casi.org/node/1924

https://lowerdementiarisk.com/understanding-mthfr-and-its-impact-on-brain-health/