Excluding death of a loved one, what is the saddest thing that could happen to a person?

Existing instead of truly living. There's nothing more sad than that.

Finding out the only person they had their side actually wasn’t on their side and didn’t care at all.

when they find out that even their very best efforts at work or love...aren't good enough, and nobody cares.

No loved ones to lose.

Losing your home.

coma, Alzheimer's, lost of all senses....

.. losing oneself. Hating oneself. Losing the will to live!..is the saddest thing besides a death of a loved one!

The air conditioner going out on a 115 day....

Abandoned from family, having no money, misery all around with depression and no help or hopes in life.

Manchester United failing to win the Premiership again :(

Vegetable like paralysis

Alzheimer's or dementia.

Mental illness.

A disfiguring/dismembering accident or massive stroke.

Divorces are horrible

An early death