My friend did it and we chatted multiple times a day during her trip.
I get it. You get to pull up to a beach or a nice spot in the mountains... all is great.
But then you got to dump your crap at dumping stations. Take care of flat tires. Drag a car with you (if you have a big RV). Drive like a truck driver. Finding free sites. Parking remotely but people try to break in when you're in the vehicle. All of the expense...
Plane/Train/Automobile + Airbnb/Hotels across the country. That's what I'd do.