What's the best way to break a generational curse?

I'm just learning (for the first time) that low self-esteem runs in my family. Even though I am fully aware of predispositions (which affects our meta-cognition and natural tendencies/habits), I'm not sure how this one is possible. Now I have to watch my back, more than before. I might start splitting myself in half (live outside my body) and make sure I don't do something foolish around people (especially those who are dear to me).

OK, I'm a little panicked so I'll stop. How do you move past a generational curse?