Are humans fundamentally different from other animals?

I'm just curious on your guys's thoughts on this idea. It can be taken from a philosophical, scientific, psychological, religious, or other perspective. I'm interested in all of them. I ask that y'all include what you consider "fundamental," because what's fundamental to one person may not be the same as what's fundamental to another, and humans and other animals may or may not be fundamentally different depending on what you consider fundamental. Have at it.