The first female bare knuckle boxers were in the 18th century.

Elizabeth Wilkinson only fought men because no women were in fighting sports yet. Her fights became absolutely legendary and proved that women could compete with males. Back in her time though, fighting was considered the same as being a wh-re, it was frowned upon but she did it anyways. She finally fought a few females later into her career. Back in those days, the fighting was actually very brutal, they started the first round with sword fighting, the first person who draws blood first, they go first. There were several ways to end a fight. They also fought with cudgels or a quarter staff.

Elizabeth Wilkinson Stokes Proved Women Can Compete With Men in Combat Sports in the 18th Century:

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Fifty years before the United States declared its independence from Britain, a woman named Elizabeth Wilkinson Stokes declared her independence from corsetry, social conventions, and the belief that women can't beat men in a fight. She tore through her opposition like xenomorph blood through a Space Marine's armor and eventually became one of the two most famous fighters of that century, as well as one of its most sought-after fight instructors.