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What does it mean when everyone I've ever loved gave up on me?

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GeniUs · 56-60, M
Do you watch South Park? The guys there explain it way better than I could but briefly put one of the boys becomes depressed (not his fault his parents screwed him up), his friends put up with him for so long but his miserable outlook (again not his fault he is genuinely depressed) starts dragging them down so they start to avoid him.