I think you have to be steadfast in your convictions and be prepared to confront all those around you of the things you feel are important to you.

You have to be able to tell your parents that YOU chose your wife and you don't need their approval on your choice.
Tell them that even if they dislike your wife, they should at least afford her the respect you give her.

It's a fact (whatever your culture) that parents rarely approve of their children's choices. In anything ! Especially their choice in partner !
Because in their eyes, nobody is ever going to be good enough for their little boy.

Make contact with your Sister. Not because it's a sign of 'weakness' but because this is you being the better man !
They'll understand that this is just you being an adult, Strong in your convictions. And they'll respect that.

I don't know what it is you do for a career but you should press on with making it your own.
Again. Be strong in your conviction that this is what you want to do and you're determined to do it.

People can be exhausting. Especially when wrapped up in their own little worlds. You mentioned this yourself when you said you didn't think your parents had enough to do.
i would normally suggest you engage your parents in discussing what they'd like to do. however i think (if you follow my advice) they're going to be busy enough trying to work out who the new you is before you get to all that.

Try it.

My parents and my grandma didn't want me to marry my husband. They wanted me to marry up. But at least they respected my decision and respected him. They didn't hate him. They just thought I could do better.

My parents were unable to accept my interracial marriage.

I solved the problem by keeping it from them. Now they’re dead and it’s no longer an issue.