Why does depression make it so people have no energy?

For example, lately, I have had no energy to do things that shouldn't be an issue for me like practicing my chorus music, and I love singing.

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cherokeepatti · 61-69, F

I believe it has something to do with neurotransmitter and hormonal imbalance, the reason that medications don't work for a lot of people is that they need to get all of them in balance.