HIV was identified in 1984. Researchers have yet to develop a vaccine. Does the public understand that developing a vaccine isn't necessarily easy?
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Kazuya69 · 31-35, M
Yes but HIV is alot different. Also its to a point where they can manage it for years so people with it pretty much can life a normal life.
Covid-19 on the other hand is a novel strain of other existing cronaviruses, It's nearly identical in most aspects, so reasearchers already know exactly where to start and pretty much what they have to do. Its just a matter of isolating the antigens, and finding a way to make them innate. Same way they did was mers, and sars
Covid-19 on the other hand is a novel strain of other existing cronaviruses, It's nearly identical in most aspects, so reasearchers already know exactly where to start and pretty much what they have to do. Its just a matter of isolating the antigens, and finding a way to make them innate. Same way they did was mers, and sars
flipper1966 · M
Not sure that's exactly right. HIV is related to Human T-cell Lymphotrophic Virus 1 (HTLV-1), the etiologic agent of Adult-T cell Leukemia/Lymphoma (ATL). THERAVECTYS has developed an anti-HTLV-1 vaccine, based on its lentiviral vector technology inducing a broad, intense and long-lasting cellular immune response after intra-muscular injection.
So HIV is an example of a virus that has eluded a vaccine -- but researchers were able to develop a vaccine to the related virus, HTLV.
Simply because you can create a vaccine for a virus doesn't mean it's necessarily easy to create a vaccine for a related virus.
So HIV is an example of a virus that has eluded a vaccine -- but researchers were able to develop a vaccine to the related virus, HTLV.
Simply because you can create a vaccine for a virus doesn't mean it's necessarily easy to create a vaccine for a related virus.
Kazuya69 · 31-35, M
@flipper1966 THERAVECTYS was the first company to have launched a clinical trial based on lentiviral vectors technology with the [b]THV01 vaccine for the treatment of HIV[/b] , [b]the THV02 vaccine for the HTLV-1 was developed from the THV01[/b].
For those who dont know, Lentiviral vectors are a type of retrovirus that insert their dna into cells in order to propagate via protein. From these proteins you get short chains of amino acids, that form peptides. When many of these amino acids chain together they create polypeptides. These for the building blocks for the proteins that retroviruses use. So Thv02 for HTLV and THv01 for HIV are therapeutic vaccines, designed to stimulate cd8 t cell response via the cytokines that help educe an immuno response.
Basically these are designed to help the body boost immune cell production of cells that can recognize infected cells, and yes the relationship of htlv-1 and hiv-1 were connected in the development of these immnotheorpy processes. antiretroviral treatment via therapeutic vaccines and other forms of antiretroviral treatments are the current way which HIV positive patience can achieve remission.
The antigen response has been different from HIV vs HTLV which is why there is differences in effectiveness. Since Isolating the peptide sequences that the immune system can recognize is difficult, so even if both viruses work the same way they dont use the same protin structures.
For those who dont know, Lentiviral vectors are a type of retrovirus that insert their dna into cells in order to propagate via protein. From these proteins you get short chains of amino acids, that form peptides. When many of these amino acids chain together they create polypeptides. These for the building blocks for the proteins that retroviruses use. So Thv02 for HTLV and THv01 for HIV are therapeutic vaccines, designed to stimulate cd8 t cell response via the cytokines that help educe an immuno response.
Basically these are designed to help the body boost immune cell production of cells that can recognize infected cells, and yes the relationship of htlv-1 and hiv-1 were connected in the development of these immnotheorpy processes. antiretroviral treatment via therapeutic vaccines and other forms of antiretroviral treatments are the current way which HIV positive patience can achieve remission.
The antigen response has been different from HIV vs HTLV which is why there is differences in effectiveness. Since Isolating the peptide sequences that the immune system can recognize is difficult, so even if both viruses work the same way they dont use the same protin structures.
flipper1966 · M
@Kazuya69 Coronaviruses and HIV are indeed similar in at least one way. They both trigger antibody-dependent enhancement:
[quote]Also, for unclear reasons, some previous vaccine candidates against coronaviruses like SARS have triggered “antibody-dependent enhancement,” which makes recipients more susceptible to infection, rather than less. In the past, vaccines against H.I.V. and dengue have unexpectedly done the same.[/quote]
[quote]Also, for unclear reasons, some previous vaccine candidates against coronaviruses like SARS have triggered “antibody-dependent enhancement,” which makes recipients more susceptible to infection, rather than less. In the past, vaccines against H.I.V. and dengue have unexpectedly done the same.[/quote]