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Exciting new depression study

This will and should change the face of mental health treatment. An umbrella study looking at a multitude od studies as well as meta-analyses has found that anti-depressants appear not to be effective for depression. This is because depression, according to the research, is not neurochemical in nature but rather situational, meaning typically accompanying a co-occurring disorder and treatable with talk therapy.

Depression, as it always has, is best treated through cognitive behavioral therapy leading to life and perception changes, which in turn lead to new behaviors. This is great material to discuss with your mental health professional or doctor. To read the study:

The serotonin theory of depression: a systematic umbrella review of the evidence
J. Moncrieff, R. Cooper, T. Stockmann, S. Amendola, M. Hengartner & M. Horowitz
Conclusion, in part:
The main areas of serotonin research provide no consistent evidence of there being an association between serotonin and depression, and no support for the hypothesis that depression is caused by lowered serotonin activity or concentrations. Some evidence was consistent with the possibility that long-term antidepressant use reduces serotonin concentration.
https://www.nature.com/articles/s41380-022-01661-0
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hartfire · 61-69
I can only say that the SSRI I'm taking has made a huge difference. I am no longer suicidal. I am no longer thinking of my situation as hopeless. I'm handling things much better and it has enabled me to get out and create a social life.
Graylight · 51-55, F
@hartfire They're not saying otherwise. They're simply suggesting it's a placebo effect or result attributed to the wrong source.

If they are correct - and this is a ground-shifting study - that serotonin plays no role in mood regulation, then a med that works on boosting serotonin levels would be effectively useless. There's no workaround for that. It may be serotonin is effective for some other uses that may act in a complimentary manner, but it's apparently not the pills working their magic.

But then, almost everyone else in the world already know that. We take more prescription drugs per capita than any other nation.