Is eating too much chips and salsa going to make me fat?

The chips will, not so much the salsa.

If it doesn't make you fat it will add to cholesterol build up.

Eventually, yes

I would say it depends on metabolism.

Oh gosh, I hope not... I had a BUNCH tonight!

technically eating too much of most anything will, given a long enough time scale.

eating too much of anything will have negative health effects

If you don't run for five miles after. Ya :)

Yes ,one day you'll look in the mirror and all you'll see is a huge gunt

No, gorge yourself.