Apart from alcohol and drug addiction what else can ruin your life ?

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Addiction
Betrayal
Cancer
Death of a loved one
Emphysema
Failure
Golf
Heart disease
Infidelity
Judgement
Karma
Lies
Misadventure
Negativity
Opprobrium ~ Public disgrace and shame
Paranoia
Quackery
Remorse
Self sabotage
Tinder
Uninsured
Vices
Widowhood
Xenophobia
Yearning
Zoonosis ~ Disease passed from animal to human