It's odd to me that US Treasury Secretary Scott Bessent is encouraging this, when he knows full well there is no legal mechanism for US states to secede from the US, in fact to join the current administration, he sold a second home in Charleston SC which had a direct view out toward Fort Sumter, where the first US civil war began because states cannot legally secede. My understanding is there is no legal means for provinces to secede from Canada either. So all of this secession or independence talk is utter rubbish.
The planet already has a ridiculous number of nations as it is, and futher splintering them into even more nations won't help anything. If anything, we need to be moving in the opposite direction, e.g., eventually all of North American should be one nation, as a stepping stone on the path of eventually dissolving all nations and admitting that this is just one planet, with one shared atmosphere, etc.