Random or systematic is what makes the difference
If things originated by random chance why is the DNA structure systematic. There are markers that lead and end genes. Random chance would just be hap hazard. And even the most basic bacteria contains 500,000 DNA base pairs. If you compare this to the dictionary which contains about 500,000 words it is not only like throwing the words in the air and having them all land in alphabetical order but also having the index markers in the right places. With or without belief in a Creator this is not a rational belief. Even for atheists with rational thought it seems there would have to be some kind of deliberate catalyst.