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Cousin Science?


[media=https://vocaroo.com/17XqlQCXoKOF]

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"user_text": "Cop should've yielded.",
"headline": "Texas Police Release Dramatic Collision Footage After 'Misinformation and Confusion'",
"url": "https://news.yahoo.com/texas-police-release-dramatic-collision-101943110.html",
"timestamp": "Wed Nov 06 13:09:33 UTC 2019"
},
{
"is_ranking_enabled": true,
"user_text": "I recommend you replace the Bible with a science textbook. You may learn something from it.",
"headline": "Republican Tate Reeves wins Mississippi governor race",
"url": "https://news.yahoo.com/republican-tate-reeves-wins-mississippi-052232036.html",
"timestamp": "Wed Nov 06 13:04:11 UTC 2019"
},

{
"is_ranking_enabled": true,
"user_text": "Whites obviously blocked the evidence from being tested.",
"headline": "Ray Cromartie: Death row inmate executed without testing DNA evidence \u2018that could have proved his innocence\u2019",
"url": "https://news.yahoo.com/ray-cromartie-death-row-inmate-093800264.html",
"timestamp": "Thu Nov 14 12:41:57 UTC 2019"
},
{
"is_ranking_enabled": true,
"user_text": "Of-course. A black man has no chance in the crooked American \"justice\" system.",
"headline": "Ray Cromartie: Death row inmate executed without testing DNA evidence \u2018that could have proved his innocence\u2019",
"url": "https://news.yahoo.com/ray-cromartie-death-row-inmate-093800264.html",
"timestamp": "Thu Nov 14 12:41:18 UTC 2019"
},
{
"is_ranking_enabled": true,
"user_text": "Lobotomies are a Republican sort of procedure.\n\nOf-course, Republicans despise science, so such procedures often ruined the \"patients\" further.",
"headline": "Former President Jimmy Carter 'up and walking' day after brain surgery, pastor says",
"url": "https://www.yahoo.com/newsroom/vibes/christian/v-bc0bb2f9-abe9-3294-a9b5-4e93082add75_c-eb4f9779-7d43-3acd-a033-aeee83b8e17a_a-eb4f9779-7d43-3acd-a033-aeee83b8e17a",
"timestamp": "Thu Nov 14 12:27:11 UTC 2019"




Subarachnoid hemorrhage (SAH) represents a major health problem in Western society due to high mortality and morbidity, and the relative young age of patients. Currently, efficacious therapeutic options are very limited. Mesenchymal stem cell (MSC) administration has been shown to improve functional outcome and lesion size in experimental models of stroke and neonatal hypoxic-ischemic brain injury. Here, we studied the therapeutic potential of intranasally administered bone marrow-derived MSCs relatively late postinsult using a rat endovascular puncture model for SAH. Six days after induction of SAH, rats were treated with MSCs or vehicle through nasal administration. Intranasal MSC treatment significantly improved sensorimotor and mechanosensory function at 21 days after SAH. Gray and white matter loss was significantly reduced by MSC treatment and the number of NeuN+ neurons around the lesion increased due to MSC treatment. Moreover, intranasal MSC administration led to a sharp decrease in SAH-induced activation of astrocytes and microglia/macrophages in the lesioned hemisphere, especially of M2-like (CD206+) microglia/macrophages. Interestingly, MSC administration also decreased SAH-induced depression-like behavior in association with a restoration of tyrosine hydroxylase expression in the substantia nigra and striatum. We show here for the first time that intranasal MSC administration reverses the devastating consequences of SAH, including regeneration of the cerebral lesion, functional recovery, and treatment of comorbid depression-like behavior.

 
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