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J&J COVID-19 vaccine is 72% effective in the U.S., 66% in overall trial

Johnson & Johnson on Friday said its single-dose vaccine was 72 percent effective in preventing COVID-19 in the United States but a lower rate of 66 percent was observed globally in the large trial conducted across three continents and against multiple variants.

In the trial of nearly 44,000 volunteers, the level of protection against moderate and severe COVID-19 was 66 percent in Latin America and just 57 percent in South Africa, where a particularly worrying variant of the novel coronavirus is circulating.

Those results compare to the high bar set by two authorized vaccines from Pfizer Inc./BioNTech SE and Moderna Inc., which were around 95 percent effective in preventing symptomatic illness in pivotal trials when given in two doses.

Those trials, however, were conducted mainly in the United States and before the broad spread of new variants now under the spotlight. J&J's main study goal was the prevention of moderate to severe COVID-19, and the vaccine was 85 percent effective in stopping severe disease and preventing hospitalization across all geographies and against multiple variants 28 days after immunization.

That level of prevention "will potentially protect hundreds of millions of people from serious and fatal outcomes of COVID-19," Dr. Paul Stoffels, J&J's chief scientific officer, said in a statement.

The company plans to seek emergency use authorization from the U.S. Food and Drug Administration next week. Public health officials have been counting on the J&J vaccine to increase much-needed supply and simplify the U.S. immunization campaign.

Unlike the Pfizer/BioNTech and Moderna vaccines, J&J's does not require a second shot weeks after the first or need to be kept frozen, making it a strong candidate for use in parts of the world with weak transportation infrastructure and insufficient cold storage facilities.
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Jimmy2016 · 61-69, M
So 75% of the people who will get the shot will be possible protected up to 72%?
cherokeepatti · 61-69, F
[@383312,Jimmy2016] crazy
SW User
[@383312,Jimmy2016] that up to the CDC If it good enough or not ....
Confined · 51-55, M
I'm not sure I believe the 95% given by the other companies. No one has any way to verify it. I'm very distrustful of being injected with an unknown chemical.
cherokeepatti · 61-69, F
SW User

Weighing the benefits and risks

All risks and side effects registered so far are only snapshots of the past months — this must be noted despite all the excitement about the rapid vaccine development. Nothing is yet known about possible long-term effects of the individual vaccines. Only the long-term studies that accompany the vaccinations worldwide and will continue since approval will provide clarity.

In principle, the decision is always based on a risk-benefit assessment, said Christian Bogdan, director of the Institute for Clinical Microbiology, Immunology and Hygiene at Erlangen University Hospital, who is also a member of the Standing Committee on Vaccination (STIKO) at the Robert Koch Institute (RKI).

To the German Press Agency, he made the following calculation: If an elderly person has a 20% chance of dying from a coronavirus infection, and at the same time the risk of getting a severe side effect of the vaccination is 1:50,000 or even less, "I would accept that risk," he said.

So far, there is a lack of information about rare, possibly severe side effects, for example in rare pre-existing conditions or in certain risk groups such as specific allergy sufferers.

Such side effects only become apparent after many people have been vaccinated and after a longer observation period. "There is therefore a residual risk," said Bogdan. "How high that is will have to be examined in the coming months and years."

When it comes to children, Bogdan said they shouldn't be vaccinated. Their risk of dying from COVID-19 is close to zero, he said, and they still have a very long life ahead of them.

Women who are pregnant or breastfeeding should also not get vaccinated as a precaution, according to Bogdan, based on current data.

A recommendation from the US Center for Disease Control (CDC), however, does not rule out vaccinating pregnant or breastfeeding mothers with mRNA vaccines after medical examination and consultation.

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