How can i help my wife ?

Make sure she knows you love her.
If you find the emotional ups and downs difficult, try to be patient and not get caught up in them yourself. Try to be there for her.
I don't know what your arrangements are with housework, cooking, and such, but try to do more than you ordinarily do, and take any burdens off her that you can.
Try to support her in taking care of herself (and the baby) physically. To rest when she needs to, and eat good food when she can.
And ask her what kind of support she would like from you.

This is an exciting and stressful time. All my good wishes for a healthy pregnancy and a healthy baby with happy parents!

A night out with your buddy's is the wrong answer. Listen to her. Help her do things she can do without asking her. Clean up after yourself. Bring her flowers and chocolate. Arrange dinner without requiring her to cook or clean up. Empathize.

Move to where she can use some cannabis.
Or ignore this because you just don't really care at all.

Doctor, make sure she's on track with her health and baby's health. Lots of cuddles, asking how she's doing, nice foot massage something like that or even flowers. Just let her know you're there for her will mean a lot