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From your perspective, how can a person thoroughly screw-up his/her life?

What is the most effective way you can come up for screwing everything in life? Explain. Thank you :)
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decidedly44
My personal response to this question is this- keep misusing and abusing God's mercy and grace, rejecting His attempts to help you and eventually you may find yourself alone and without hope, God's enemy. If The Lord leaves a person what hope is there? However, for anyone reading this, PLEASE do not conclude that this has happened to you, no matter how things appear.