Do you think intelligence can cause depression and isolation?

I'm quite certain some feelings of isolation will be formed, since perhaps some of the people we know may think we're not "like them", with our own 'different' ideals and perspectives. I highly doubt it will cause depression, though the only possible way related, is if the isolation gets a bit too much to handle. Since there's a lot of stuff that the intelligent individual observes, and wants to learn, I don't think there is much room for depression to come in. Just my opinion :D